To study the effect of Kamidaebotang on the hypothyroidism induced by thiourea in SD(Splague Dawley) rats, the weight of thyroid gland, the level of serum . total cholesterol, hematological changes and histopathological findings were measured.
The following results were obtained.
1. Thyroid gland weight of the Kamidaebotang B treated group was significantly increased as compared with that of control group(p<0.05).
2. The level of serum of the Kamidaebotang B treated group was slightly increased as compared with that of control group. But no significant changes appeared between two groups.
3. The level of serum of the Kamidaebotang A, B treated groups were significantly increased as compared with that of control group(p<0.05).
4. Total cholesterol of the Kamidaebotang A, B treated groups were not significant changes as compared with that of control group.
5. Hematological data of the Kamidaebotang A, B treated groups were not significant changes as compared with that of control group.
6. Histopathologically, Kamidaebotang B administration recovered effectly the dystropy, degeneration of thyroid follicle induced by thiourea.
From above results, it is suggested that Kamidaebotang B is available to the hypothyroidism induced by thiourea in rats. Therefore, Kamidabotang B seems to be applicable to hypothyroidism in clinical practice.
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